This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison.
What is gene ontology (GO)?
Gene ontology (GO) is a bioinformatic method created to provide a common language for the description of gene products. GO addresses three areas:
AmiGO, a gene ontology database, was used to determine the following GO terms and trees. Gene ontology databases use gene product data from primary literature to determine the gene terms and trees.
- Biological process- describes the gene product's involvement in organismal, tissue, and/or molecular processes
- Cellular component- describes the gene product's location in the cell or the cell's surroundings
- Molecular function- describes the gene product's function [1]
AmiGO, a gene ontology database, was used to determine the following GO terms and trees. Gene ontology databases use gene product data from primary literature to determine the gene terms and trees.
Sema5a Cellular ComponentSEMA5A is associated with one cellular component:
SEMA5A biological ProcessSEMA5A is associated with four different biological processes:
SEMA5A Molecular FunctionSEMA5A is associated with one molecular function:
DiscussionAmiGO identified several GO terms for the SEMA5A human gene, all of which were compatible with the protein domains, primary literature, and SEMA5A mutant phenotypes. SEMA5A mutation patients show disrupted neuronal guidance and abnormal vasculature patterning. Because of these disruptions, it is logical that the biological processes for the SEMA5A gene include axon guidance, branching morphogenesis of an epithelial tube, patterning of blood vessels, and signal transduction.
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Figure 1. Axon guidance gene ontology tree for human SEMA5A gene (click to enlarge).
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References
Neuron picture: http://paperstack.org/wp-content/uploads/2015/01/173_neurons.jpg
[1] Gene Ontology Consortium. (n.d.). Retrieved March 24, 2015, from http://geneontology.org/
Interactive map: http://www.reactome.org/PathwayBrowser/#DIAGRAM=373755&ID=416696&DTAB=EX
[1] Gene Ontology Consortium. (n.d.). Retrieved March 24, 2015, from http://geneontology.org/
Interactive map: http://www.reactome.org/PathwayBrowser/#DIAGRAM=373755&ID=416696&DTAB=EX